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Title: A novel drug delivery system using acyclovir nanofiber patch for topical treatment of recurrent herpes labialis: A randomized clinical trial
Journal: Clinical and experimental dental research
Author: Zahra Golestannejad,Faezeh Khozeimeh,Mohammad Mehrasa,Shahla Mirzaeei,Dorna Sarfaraz
Year: 2022
Address: 1.Department of Oral Medicine, DentalResearch Center, School of Dentistry, IsfahanUniversity of Medical Sciences, Isfahan, Iran 2.Department of Biotechnology, School ofAdvanced Sciences and Technologies,University of Isfahan, Isfahan, Iran 3.Pharmaceutical Sciences Research Center,Health Institute, Kermanshah University ofMedical Sciences, Kermanshah, Iran 4.Dental Students Research Committee, Schoolof Dentistry, Isfahan University of MedicalSciences, Isfahan, Iran
Abstract: Objectives:Topical treatment with acyclovir cream has shown low efficacy in recentstudies. Nano drug delivery systems, have received much attention in recent decades.The aim of this study was to compare the efficacy of acyclovir nanofiber patch withacyclovir cream.Material and Methods:In this double-blind three-armed randomized clinical trial, atotal of 60 patients with recurrent labial herpes, were randomly divided into threegroups, each consisting of 20. The patients in the first, second, and third groups weretreated with acyclovir nanofiber patch, placebo nanofiber patch, and acyclovir cream,respectively. A numerical scale was used by the patients to record the self-reportedsymptoms. Symptoms score, crusting time and healing time were assessed by the cli-nician. Kruskal-Wallis test was used to compare the symptoms between the threegroups, a survival test was also performed to evaluate the crusting and healing time.Data were analyzed in SPSS V22 atP-value < 0.05.Results:The mean scores of symptoms at baseline were 1.6, 1.5, and 1.4 in the first,second, and third groups, respectively. The symptoms were not significantly differentbetween the three groups on different treatment days. The mean crusting time was2.3, 2.4, and 2.6 days in the three groups, and the mean healing time was 7.4, 7.2,and 7.7 days, respectively. Crusting time and healing time were not significantly dif-ferent between the three groups.Conclusions:Acyclovir nanofiber patches are recommended for accelerating symp-tom relief in recurrent labial herpes, however, they are not effective in shortening thecrusting or healing time.
Keywords: Acyclovir, Herpes labialis, Nanostructured Drug delivery, Patch
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: #https://onlinelibrary.wiley.com/doi/full/10.1002/cre2.512#