ISI Papers With Our Products

Title: Nanofibrous chitosan/polyethylene oxide silver/hydroxyapatite/silica composite as a potential biomaterial for local treatment of periodontal disease
Journal: Polymer Bulletin
Author: Fatemeh Hakimi, Samaneh Hashemikia, Somayeh Sadighian & Ali Ramazani
Year: 2022
Address: 1.Student Research Committee, Zanjan University of Medical Sciences, Zanjan, Iran 2.Department of Pharmaceutical Biomaterials, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran 3.Department of Textile Engineering, Urmia University of Technology, Urmia, Iran 4.Department of Pharmaceutical Biotechnology, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran
Abstract: Periodontal disease is a set of inflammatory conditions affecting the tissues surrounding the teeth, which can be fairly preventable. In this research, antibacterial polymeric nanofibers were prepared for the management of periodontal disease treatment. New hybrid organic/inorganic nanofibers of chitosan/polyethylene oxide (CS/PEO) contains doxycycline hyclate (DOXH) (as an antibacterial drug) and silver/hydroxyapatite/silica (Ag/HA/Si) nanocomposite (CS/PEO-DOXH-Ag/HA/Si) fabricated by electrospinning technique. The nanofibers were characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), field emission scanning electron microscope (FE-SEM), thermogravimetric analysis (TGA) and transmission electron microscopy (TEM). In vitro release profile, degradation (DE) test, swelling (SW) test, antimicrobial activity and cell viability were also obtained. The DOXH release profile was measured by ultraviolet visible (UV–Vis) spectrophotometer in artificial saliva (pH 6.8) at 37 °C. The application of Ag/HA/Si increased the morphological integrity during the degradation process and decreased the rate of drug delivery. The electrospun nanofibers showed an enhanced antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Streptococcus mutans (S. mutans) bacterium strains with the lowest DOXH amount, which can reduce the high dosage of antibiotics and side effects. Cell viability assays revealed that the prepared nanofibers had no cytotoxicity against the human gingival fibroblast 2 (HGF-2) cell line. The results suggest that the prepared organic/inorganic hybrid nanofibers with drug delivery properties could be a promising candidate for the treatment of periodontal diseases.
Keywords: Chitosan, Hybrid nanofiber, Local drug delivery, Periodontal disease
Application: Drug Delivery
Product Model 1: Electroris(ES-1000)
Product Model 2:
URL: #https://link.springer.com/article/10.1007/s00289-022-04466-x#