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Title: Electrospun PVP/PVA nanofiber mat as a novel potential transdermal drug-delivery system for buprenorphine: A solution needed for pain management
Journal: Applied Sciences
Author: 1. Fatemeh Rahmani, 2. Hakimeh Ziyadi, 3. Mitra Baghali, Seeram Ramakrishna, 4. Hongrong Luo
Year: 2021
Address: 1. Pharmaceutical Sciences Research Center, Tehran Medical Sciences, Islamic Azad University, Tehran 1941933111, Iran
2. Department of Organic Chemistry, Faculty of Pharmaceutical Chemistry, Tehran Medical Sciences, Islamic Azad University, Tehran 1913674711, Iran
3. Center for Nanotechnology and Sustainability, Department of Mechanical Engineering, National University of Singapore, Singapore 117576, Singapore
4. National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, China
Abstract: Over the past several decades, the formulation of novel nanofiber-based drug-delivery systems has been a frequent focus of scientists around the world. Aiming to introduce a novel nanofibrous transdermal drug-delivery system to treat pain, the nanofiber mats of buprenorphine-loaded poly (vinyl pyrrolidone) (Bup/PVP) and buprenorphine-loaded poly(vinyl alcohol)/poly(vinyl pyrrolidone) (Bup/PVP/PVA) were successfully fabricated by the electrospinning process for transdermal drug delivery. Similarly, PVP and PVP/PVA nanofibers were fabricated in the same conditions
for comparison. The viscosity and electrical conductivity of all electrospinning solutions were measured,
and nanofiber mats were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), Fourier transform infrared (FT-IR) spectroscopy and contact angle analysis. The
conductivity of PVP and PVP/PVA solutions showed a considerable increase by the addition of buprenorphine due to the polarity of buprenorphine. SEM images showed a smooth, fine and porous
nanofibrous structure without any adhesion or knot for all of the samples. The contact angle analysis showed the increased hydrophilicity and wettability of PVP/PVA and Bup/PVP/PVA nanofibers
compared to PVP and Bup/PVP nanofibers which can be attributed to the addition of PVA. Attenuated total reflectance (ATR) FT-IR results confirmed that the electrospinning process did not affect the chemical integrity of the drug. For the modification of the drug release rate, the cross-linking of nanofiber mats was carried out using glutaraldehyde. Drug release measurements using highperformance liquid chromatography (HPLC) analysis demonstrated that Bup/PVP/PVA nanofibers exhibited better physical and chemical properties compared to Bup/PVP. Furthermore, the crosslinking of nanofibers led to an increase in drug release time. Thus, the novel buprenorphine-loaded nanofibers can be efficient biomaterial patches for transdermal delivery against pain improving carrier retention and providing a controlled release of the drug.
Keywords: nanofibers, Buprenorphine, poly (vinyl pyrrolidone) poly (vinyl alcohol), drug delivery
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: #https://www.mdpi.com/2076-3417/11/6/2779#