ISI Papers With Our Products
Title: Preparation of Polyurethane/Pluronic F127 Nanofibers Containing Peppermint Extract Loaded Gelatin Nanoparticles for
Diabetic Wounds Healing: Characterization, In Vitro, and In
Vivo Studies
Journal: Evidence-Based Complementary and Alternative Medicine
Author: 1. Arash Almasian, Mohammad Reza Shams Ardekani, 2. Farhood Najafi, 3. Mahdieh Eftekhari, Mohammad Sharifzadeh, 5,6. Mahnaz Khanavi
Year: 2021
Address: 1. Department of Pharmacognosy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Resin and Additives, Institute for Color Science and Technology, Tehran, Iran
3. Department of Pharmacognosy, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Tehran, Iran
4. Department of Toxicology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Pharmacognosy, Faculty of Pharmacy and Persian Medicine and Pharmacy Research Center, Tehran University of Medical Sciences, Tehran, Iran
6. Faculty of Land and Food Systems, University of British Columbia, Vancouver, Canada
Abstract: Diabetic ulcer is regarded as one of the most prevalent chronic diseases. 'e healing of these ulcers enhances with the use of herbal
extracts containing wound dressings with high antibacterial property and creating a nano-sized controlled release system. In this
study, new peppermint extract was incorporated in the polyurethane- (PU-) based nanofibers for diabetic wound healing. 'e
peppermint extract was used as an herbal antimicrobial and anti-inflammatory agent. 'e absorption ability of the wound
dressing was enhanced by addition of F127 pluronic into the polymer matrix. 'e release of the extract was optimized by
crosslinking the extract with gelatin nanoparticles (CGN) and their eventual incorporation into the nanofibers. 'e release of the
extract was also controlled through direct addition of the extract into the PU matrix. 'e results showed that the release of extract
from nanofibers was continued during 144 hours. 'e prepared wound dressing had a maximum absorption of 410.65% and an
antibacterial property of 99.9% against Staphylococcus aureus and Escherichia coli bacteria. An in vivo study indicated on
significant improving in wound healing after the use of the extract as an effective compound. On day 14, the average healing rate
for samples covered by conventional gauze bandage, PU/F127, PU/F/15 (contained extract), and PU/F/15/10 (contained extract
and CGN) prepared with different nanoparticle concentrations of 5 and 10 was 47.1 ± 0.2, 56.4 ± 0.4, 65.14 ± 0.2, and
90.55 ± 0.15%, respectively. Histopathological studies indicated that the wound treated with the extract containing nanofibers
showed a considerable inflammation reduction at day 14. Additionally, this group showed more resemblance to normal skin with
a thin epidermis presence of normal rete ridges and rejuvenation of skin appendages. Neovascularization and collagen deposition
were higher in wounds treated with the extract containing nanofibrous wound dressing compared to the other groups.
Keywords:
Application: Wound Dressing
Product Model 1: Electroris
Product Model 2:
URL: #https://www.hindawi.com/journals/ecam/2021/6646702/#