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Title: Cytotoxic effects of chitosan nanoparticles containing Zataria multiflora essential oil against human breast and melanoma cells
Journal: Beni-Suef University Journal of Basic and Applied Sciences
Author: 1. Hiva Alipanah, 2. Fatemeh Yarian, 3. Fatemeh Rasti, 4. Mojdeh Safari, 5. Shekoufeh Hatami, 6. Mahmoud Osanloo
Year: 2022
Address: 1. Department of Physiology, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran. 2 Department of Medical Biotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran. 3. Noncommunicable Diseases Research Center, Fasa University of Medical Sciences, Fasa, Iran. 4. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran. 5. Department of Biochemistry, School of Medicine, Fasa University of Medical Science, Fasa, Iran. 6. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Abstract: Background: Breast cancer is the most common cancer among women, and melanoma incidence increases worldwide. The emergence of drug resistance and side effects of chemotherapy drugs has led to a great deal of attention being paid to the development of natural medicines, especially using essential oil. The preparation of essential oilbased nanoformulation has thus recently received more attention. Results: In this study, chitosan nanoparticles (ChiNPs) containing Zataria multiflora essential oil with a particle size of 177 ± 10 nm, a narrow particle size distribution (SPAN 0.96), and a cubic-like shape were first prepared. IC50 values of the prepared nanoformulation against human melanoma (A-375) and breast cancer cell lines (MCF-7 and MDA-MB-468) were obtained as 32 (12–84), 46 (32–67), and 105 (85–131) μg/mL. Besides, an electrospun polycaprolactone– polyethylene oxide scaffold was prepared as a dressing after treatment with the nanoformulation. Fourier transform infrared analysis confirmed the scaffold’s preparation as well as successful loading of the essential oil in chitosan nanoparticles. Furthermore, the scaffold did not show a cytotoxic effect on A-375, MCF-7, and MDA-MB-468, and its surface was hydrophobic as the water contact angle with the surface was 136.5°. Conclusions: The prepared prototype with natural ingredients and high efficacy could be considered for further consideration in vivo study or complementary medicine.
Keywords: Skin cancer, Electrospun nanofibers, Neoplasm, Natural anticancer
Application: Scaffold
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URL: #https://bjbas.springeropen.com/articles/10.1186/s43088-022-00241-z#