ISI Papers With Our Products
Title: Bioinspired immobilization of carbon nanotubes on scaffolds for nerve regeneration
Journal: Bioinspired, Biomimetic and Nanobiomaterials
Author: 1. Niloofar Nazeri, 1,5,6. Hossein Ghanbari, 2. Roksana Tajerian, Zohreh Arabpour, 3. Mahmoud Reza
Hadjighassem, Mahboubeh Manouchehrabadi 4. Nematollah Gheibi
Year: 2019
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Tissue Engineering and Applied Cell Sciences, Faculty of Advanced Technologies in Medicine,
Tehran University of Medical Sciences, Tehran, Iran
3. Department of Neuroscience, School of
Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Cellular and Molecular Research Center, Qazvin University of Medical Sciences, Qazvin, Iran
5. Medical Biomaterials Research Center (MBRC), Tehran University of Medical sciences, Tehran, Iran
6. Research Center for Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical sciences, Tehran, Iran
Abstract: Carbon nanotubes (CNTs) have different applications in regenerative neurology such as neural signal transfer, nerve tissue engineering and neuroprosthetic devices. Their electrical conductivity and biocompatibility make them appropriate candidates for cell stimulation. This study was conducted to determine whether polydopamine (PD) can immobilize CNTs on the surface of nanofibrous scaffolds. To investigate this, electrospun scaffolds of poly(lactide-co-glycolide) (PLGA) were coated with CNTs both directly and by means of PD. Scanning electron microscopy (SEM), water contact angle measurement and Raman spectroscopy were used to verify the presence of dopamine on the surface of the scaffolds. The presence of PD on the substrate surface decreased the contact angle from 135·92 ± 2 to 82·65 ± 2°. Raman spectroscopy confirmed results by appearance of new peaks at 1350 and 1582 cm−1, which correspond to the aromatic component of PD. Measuring the electrical resistance proved that dopamine could effectively immobilize CNTs on the surface of nanofibers, decreasing the electrical resistance to 5·5 kΩ/square. Likewise, SEM images revealed a change in surface morphology induced by PD coating. Finally, cell viability studies demonstrated that CNT–PD–PLGA had no toxic effect on PC12 cells. The preliminary results were promising, supporting potential application of these materials as conductive scaffolds in nerve cell stimulation.
Keywords: bioinspired, nanomaterials, scaffold
Application: Tissue Engineering, Scaffold
Product Model 1: Electroris
Product Model 2:
URL: #https://www.icevirtuallibrary.com/doi/abs/10.1680/jbibn.18.00033#