ISI Papers With Our Products

Title: Development of a Novel Electroactive Cardiac Patch Based on Carbon Nanofibers and Gelatin Encouraging Vascularization
Journal: Applied Biochemistry and Biotechnology
Author: 1. Arezou Mehrabi, Zahra Amirkhani, 2. Nafiseh Baheiraei, 3. Mahdi Adabi
Year: 2020
Address: 1. Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 2. Tissue Engineering and Applied Cell Sciences Division, Department of Hematology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Abstract: Tissue engineeringmakes it possible to fabricate scaffolds that can help the function of defective tissues or even the most complex organs such as the heart. Carbon nanofibers (CNFs), because of their high mechanical strength and electrical properties, can improve the functional coupling of cardiomyocytes and their electrophysiological properties. In this study, electroactive CNF/gelatin (Gel) nanofibrous cardiac patches were prepared by an electrospinning method. Scanning electron microscope (SEM) evaluation of prepared scaffolds showed randomly oriented nanofibers. The electrical conductivity of the CNF/Gel scaffolds was assessed by a four-probe device and was in the semiconducting range (~ 10−5 S/m). The result of an MTT assay confirmed the excellent biocompatibility of electroactive CNF/ Gel scaffolds. Also, CNF-containing scaffolds supported cardiomyocyte adhesion and increased expression of the cardiac genes including TrpT-2, Actn4, and Conx43 compared with the nonconductive counterpart. Our findings also confirmed the angiogenic potential of CNF/Gel scaffolds as compatible and electroactive platforms for cardiac tissue engineering.
Keywords: Cardiac patch, Carbon nanofiber, Tissue engineering, Vascularization, Electrospinning
Application: Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL: #https://link.springer.com/article/10.1007/s12010-019-03135-6#