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Title: Development of electrically conductive hybrid nanofibers based on CNT‐polyurethane nanocomposite for cardiac tissue engineering
Journal: Microscopy research and technique
Author: 1. Nasim Shokraei, Shabnam Shokraei, Reza Faridi-Majidi, 1,4,5. Hossein Ghanbari, 2. Shiva Asadpour, 3. Mehrdad Nasrollahzadeh Sabet
Year: 2019
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran 3. Cancer Epidemiology Research and Treatment Center, Ministry of Health and Medical Education, Tehran, Iran 4. Medical Biomaterials Research Center (MBRC), Tehran University of Medical Sciences, Tehran, Iran 5. Department of Advanced Technologies in Cardiovascular Medicine, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract: Conductive nanofibers have been considered as one of the most interesting and promising candidate scaffolds for cardiac patch applications with capability to improve cell–cell communication. Here, we successfully fabricated electroconductive nanofibrous patches by simultaneous electrospray of multiwalled carbon nanotubes (MWCNTs) on polyurethane nanofibers. A series of CNT/PU nanocomposites with different weight ratios (2:10, 3:10, and 6:10wt%) were obtained. Scanning electron microscopy, conductivity analysis, water contact angle measurements, and tensile tests were used to characterize the scaffolds. FESEM showed that CNTs were adhered on PU nanofibers and created an interconnected web‐like structures. The SEM images also revealed that the diameters of nanofibers were decreased by increasing CNTs. The electrical conductivity, tensile strength, Young's modulus, and hydrophilicity of CNT/PU nanocomposites also enhanced after adding CNTs. The scaffolds revealed suitable cytocompatibility for H9c2 cells and human umbilical vein endothelial cells (HUVECs). This study indicated that simultaneous electrospinning and electrospray can be used to fabricate conductive CNT/PUnanofibers, resulting in better cytocompatibility and improved interactions between the scaffold and cardiomyoblasts.
Keywords: CNTs, electrospinning, electrospray, polyurethane, cardiac tissue engineering
Application: Tissue Engineering
Product Model 1: Electroris
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URL: #https://onlinelibrary.wiley.com/doi/abs/10.1002/jemt.23282#