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Title: Alginate-Based Hydrogel Containing Taurine-Loaded Chitosan Nanoparticles in Biomedical Application
Journal: Archives of Neuroscience
Author: 1. Arash Goodarzi, Mehdi Khanmohammadi, Somayeh Ebrahimi-Barough, Mahmoud Azami, Nasrin Lotfi bakhshaiesh, Ali Farzin, Jafar Ai, 2. Amir Amani, 3. Alireza Baradaran-Rafii, 4. Armin Ai
Year: 2019
Address: 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 3. Department of Ophthalmology and Ophthalmic Research Center, Labbafinejad Medical Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran 4. Department of Oral and Maxillofacial Surgery, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
Abstract: The hydrogel efficacy of taurine-loaded chitosan nanoparticle/alginate hydrogel was investigated for controlled release of the taurine substrate, which is known as an antioxidative drug. The composition of the fabricated hydrogels was explored by Fouriertransform infrared spectroscopy. The swelling ability and degradation rate of hydrogels were also analyzed in phosphate-buffered saline at the physiological condition and alginate lyase for a period of 21 days. Moreover, morphologies and structure of hydrogels and cells were determined using a scanning electron microscope. The possible cytotoxicity of the fabricated hydrogel was carried out by seeding endometrial stem cells on hydrogels. The results demonstrated that hydrogel of chitosan nanoparticle/alginate hydrogel successfully controlled the release of taurine. We observed that the chitosan nanoparticle/alginate hydrogel possessed adjust swelling ability and degradation rate as compared to neat alginate hydrogel. The results proved that the chitosan nanoparticle/alginate hydrogel is non-cytotoxic and could be utilized as a promising composition in tissue engineering and drug delivery systems.
Keywords: Alginate-Based Hydrogel, Chitosan Nanoparticle, Taurine, Controlled Drug Release, Cytocompatibility
Application: Tissue Engineering, Drug Delivery
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