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Title: Neural tissue regeneration by a gabapentin-loaded cellulose acetate/gelatin wet-electrospun scaffold
Journal: Cellulose
Author: 1. Saeed Farzamfar, Farshid Esmaeilpour, Hadi Samadian, 2. Mahdi Naseri-Nosar, Majid Salehi, 3. Ahmad Vaez, Arash Goodarzi, 4. Arian Ehterami, 5. Hamed Sahrapeyma, 6. Sadegh Ghorbani, Arian Azimi, 7. Amir-Ali Hamidieh
Year: 2018
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud 3613773955, Iran 3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 4. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 5. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 6. Hematology, Oncology and Stem Cell Transplantation Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran 7. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract: In the present study, gabapentin (GBP), an anticonvulsant drug used as an analgesic to control the neuropathic pains, was incorporated with cellulose acetate (CA) and gelatin (Gel) in order to develop a potential scaffold for neural tissue engineering applications. The wet-electrospinning method was used to produce the drug-loaded three dimensional scaffolds from CA/Gel [1:1 (w/w)] solution in the water/ethanol (3:7) (v/v) coagulation baths containing 3%, 6% and 12% (w/v) of GBP. The scaffolds were evaluated regarding their morphology, contact angle, porosity, tensile strength and cellular response. The scaffold obtained from 6% (w/v) GBP bath was chosen as the optimum scaffold for further in vivo study in a sciatic nerve defect model in Wistar rats. The results of sciatic functional index, hot plate latency, weight-loss percentage of the wet gastrocnemius muscle and the histopathological examination using hematoxylin– eosin staining demonstrated that the GBP-containing scaffold significantly enhanced the regeneration of the created injury, which demonstrates its applicability for neural tissue engineering applications.
Keywords: Cellulose acetate, Gabapentin, Gelatin, Neural tissue engineering scaffold, Wet-electrospinning
Application: Tissue Engineering, Scaffold
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URL: #https://link.springer.com/article/10.1007/s10570-017-1632-z#