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Title: In vitro and in vivo evaluation of electrospun cellulose acetate/gelatin/hydroxyapatite nanocomposite mats for wound dressing applications
Journal: Artificial Cells, Nanomedicine, and Biotechnology
Author: 1. Hadi Samadian, 2,3. Majid Salehi, 4. Saeed Farzamfar, Ahmad Vaez, Arash Goodarzi, 5. Arian Ehterami, 6. Hamed Sahrapeyma, 7. Sadegh Ghorbani
Year: 2018
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran 3. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran 4. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 5. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 6. Department of Biomaterial Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 7. Department of Anatomical Sciences, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran
Abstract: The present study aimed to evaluate the efficacy of cellulose acetate/gelatin/nanohydroxyapatite (CA/Gel/nHA) nanocomposite mats as the wound dressing. The dressings were prepared with electrospinning of CA/Gel solutions containing 12.5, 25 and 50mg nHA. The dressings were evaluated regarding their water uptake capacity, morphology, tensile strength, water vapour transmission rate, wettability and cellular response with L929 cell line. The results showed that the concentration of nHA had a direct correlation with porosity, water contact angle, water uptake, water vapor transmission rate and proliferation. In vivo studies showed that all dressings had higher wound closure percent than the sterile gauze, as the control. The highest wound closure value was achieved in the CA/Gel þ25mg nHA group, which showed 93.5 ± 1.6%. The histological and the histomorphometric examinations of the wounds revealed that the CA/Gel þ25mg nHA dressing had the greatest collagen synthesis, re-epithelialization, neovascularization and also the best cosmetic appearance. Based on our finding, it could be concluded the applicability of electrospun nanofibrous CA/Gel/nHA dressings for successful wound treatment.
Keywords: Cellulose acetate, gelatin, hydroxyapatite, electrospinning, wound dressing, histomorphometric examination
Application: Wound Dressing
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URL: www.tandfonline.com/doi/abs/10.1080/21691401.2018.1439842#http://www.tandfonline.com/doi/abs/10.1080/21691401.2018.1439842#