ISI Papers With Our Products

Title: The antibacterial and anti-inflammatory investigation of Lawsonia Inermis-gelatin-starch nano-fibrous dressing in burn wound
Journal: International journal of biological macromolecules
Author: 1. Zhina Hadisi, Jhamak Nourmohammadi, 2. Seyed Mahdi Nassiri
Year: 2018
Address: 1. Faculty of New Sciences and Technologies, Department of Life Science Engineering, University of Tehran, Tehran, Iran. 2. Department of Clinical Pathology, Faculty of Veterinary Medicine, University of Tehran, Iran
Abstract: The aim of this study was to develop a new bioactive gelatin-oxidized starch nanofibers containing Lawsonia Inermis (henna) for treating second-degree burn wounds. Continuous, smooth, and bead-free fibers were obtained when the gelatin-starch ratio was 70/30. Additionally, the fiber dimeter was reduced with increasing henna content. The successful loading of henna in the gelatin-oxidized starch nanofibers was approved using Fourier transform infrared spectroscopy and Differential scanning calorimetry. Moreover, the addition of henna to the gelatin-oxidized starch nanomatrix enhanced fibroblasts attachment, proliferation, collagen secretion, and antibacterial activity. In vivo studies showed that the nanofibers loaded with henna accelerated wound closure remarkably with the absence of detrimental suppurative reaction at the site of the burn wound. The CD68 immunohistochemical stained wound images showed that treating the burn wound sites with gelatin-oxidized starch-henna reduced the inflammatory response and macrophage numbers significantly.
Keywords: Anti-inflammatory, Antibactrial activity, Burn wound.
Application: Wound Dressing
Product Model 1: Electroris
Product Model 2:
URL: #https://www.sciencedirect.com/science/article/pii/S0141813017318202#