ISI Papers With Our Products

Title: Naringin-loaded Poly(ε caprolactone)/Gelatin Electrospun Mat as a Potential Wound Dressing: In vitro and In vivo Evaluation
Journal: Fibers and Polymers
Author: 1. Majid Salehi, Mahdi Naseri-Nosar, 2. Ahmad Vaez, Jafar Ai, Somayeh Ebrahimi-Barough, 3. Saeed Farzamfar, 4. Arman Ai, 5. Shima Tavakol, 6. Mehrdad Khakbiz
Year: 2018
Address: 1. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud 3613773955, Iran 2. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran 1417755469, Iran 4. School of Medicine, Tehran University of Medical Sciences, Tehran 141556447, Iran 5. Cellular and Molecular Research Center, Iran University of Medical Sciences, Tehran 354-14665, Iran 6. Division of Biomedical Engineering, Department of Life Science Engineering, Faculty of New Sciences and Technologies, University of Tehran, Tehran 143951561, Iran
Abstract: In the present study, naringin, a flavonoid isolated from the grape and citrus fruit species, was incorporated with poly(ε-caprolactone)/gelatin composite mats in order to develop a potential wound dressing. The composite mats were prepared by electrospinning of poly(ε-caprolactone)/gelatin (1:1 (w/w)) solution incorporated with 1.50 %, 3 % and 6 % (w/w) of naringin. The electrospun mats were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile properties, drug release, cellular response and in vivo wound healing activity. The study showed that after 2 weeks, the full-thickness excisional wounds of Wistar rats treated with the naringin-loaded dressings achieved a wound closure of higher than 94 % and the dressing containing 6 % (w/w) naringin had almost 100 % wound closure. The sterile gauze, as the control group, showed nearly 86 % of wound closure after this period of time. Our results provided evidence that supports the possible applicability of naringin-loaded wound dressing for successful wound treatment.
Keywords: Electrospinning, Gelatin, Naringin, Poly(ε-caprolactone), Wound dressing
Application: Wound Dressing
Product Model 1: Syringe Pump
Product Model 2: High Voltage Power Supply
URL: #https://link.springer.com/article/10.1007/s12221-018-7528-6#