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Title: Kaolin-loaded chitosan/polyvinyl alcohol electrospun scaffold as a wound dressing material: in vitro and in vivo studies
Journal: Journal of Wound Care
Author: 1,2. Majid Salehi, 3. Saeed Farzamfar, 4. Arian Ehterami, 5,6. Zahrasadat Paknejad, 7,8. Farshid Bastami, 9,10. Sadegh Shirian, 11. Hamid Vahedi, 12. Gholamreza Savari Koehkonan, 13. Arash Goodarzi
Year: 2020
Address: 1 Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran
2. Tissue Engineering and Stem Cell Research Center, Shahroud University of Medical Sciences, Shahroud, Iran
3. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Mechanical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
5. Medical Nanotechnology and Tissue Engineering Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
7. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Behesti University of Medical Sciences, Tehran, Iran
8. Oral and Maxillofacial Surgery Department, School of Dentistry, Shahid Beheshti University of Medical Sciences,
Tehran, Iran
9. Department of Pathology, School of Veterinary Medicine, Shahrekord
University, Shahrekord, Iran
10. Shiraz Molecular Pathology Research Center, Dr. Daneshbod Pathology Lab, Shiraz, Iran
11. Clinical Research Development
Unit, Imam Hossein Hospital, Shahroud University of Medical Sciences, Shahroud,
Iran
12. Department of Medical Nanotechnology, Islamic Azad University Tehran branch, Tehran, Iran
13. Department of Tissue Engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran
Abstract: Objective: To evaluate the application of a fabricated dressing containing kaolin for skin regeneration in a rat model of excisional wounds.
Method: In the present study, kaolin was loaded into electrospun polyvinyl alcohol (PVA)/chitosan polymer blend to develop a composite nanofbrous dressing. To make the yarns, kaolin with weight ratio of 5% was added to PVA/chitosan polymer blend and subsequently formed into nanofbres using the electrospinning
method. Scaffolds were evaluated for to their microstructure, mechanical properties, surface wettability, water vapour transmission rate, water-uptake capacity, blood uptake capacity, blood
compatibility, microbial penetration test, the number of colonies, and cellular response with the L929 cell line. Rats with full-thickness excisional wounds were treated with kaolin-containing and kaolinfree dressings.
Results: The study showed that rats treated with the kaolinincorporated mats demonstrated a signifcant closure to nearly 97.62±4.81% after 14 days compared with PVA/chitosan and the
sterile gauze, which showed 86.15±8.11% and 78.50±4.22% of wound closure, respectively. The histopathological studies showed that in the PVA/chitosan/kaolin group, dense and regular collagen fibres were formed, while wounds treated with sterile gauze or PVA/chitosan scaffolds had random and loose collagen fbres.
Conclusion: Our results show the potential applicability of PVA/chitosan/kaolin scaffolds as a wound care material.
Keywords: chitosan, electrospinning, nanofibrous, polyvinyl alcohol, wound dressing, wound healing
Application: Wound Dressing
Product Model 1: High Voltage Power Supply
Product Model 2: Syringe Pump
URL: #https://www.magonlinelibrary.com/doi/abs/10.12968/jowc.2020.29.5.270#