ISI Papers With Our Products

Title: Unrestricted Somatic Stem Cells Loaded in Nanofibrous Conduit as Potential Candidate for Sciatic Nerve Regeneration
Journal: Journal of Molecular Neuroscience
Author: 1. Saeed Farzamfar, Ahmad Vaeez, 2. Arian Ehterami, 3,4. Majid Salehi, 4,5. Amir Atashi, 6. Hamed Sahrapeyma
Year: 2019
Address: 1. Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Mechanical and Aerospace Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran 3. Department of Tissue Engineering, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran 4. Tissue Engineering and Stem Cells Research Center, Shahroud University of Medical Sciences, Shahroud, Iran 5. Department of Hematology, School of Medicine, Shahroud University of Medical Sciences, Shahroud, Iran 6. Department of Biomedical Engineering, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract: Motor and sensory recovery following critical size peripheral nerve defects is often incomplete. Although nerve grafting has been proposed as the gold standard, it is associated with several disadvantages. Here we report a novel approach to peripheral nerve repair using Human Unrestricted Somatic Stem Cells (USSC) delivered through an electrospun neural guidance conduit. Conduits were produced from PCL and gelatin blend. Several in vitro methods were utilized to investigate the conduit’s physicochemical and biological characteristics. Nerve regeneration was studied across a 10-mm sciatic nerve gap in Wistar rats. For functional analysis, the conduits were seeded with 3 × 104 USSCs and implanted into a 10-mm sciatic nerve defect. After 14 weeks, the results of functional recovery analysis and histopathological examinations showed that animals implanted with USSC containing conduits exhibited improved functional and histopathological recovery which was more close to the autograft group compared to other groups. Our results support the potential applicability of USSCs to treat peripheral nerve injury in the clinic.
Keywords: Unrestricted somatic stem cells, Neural guidance conduits, Electrospinning, Peripheral nerve regeneration
Application: Tissue Engineering, Scaffold
Product Model 1: Syringe Pump
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URL: #https://link.springer.com/article/10.1007/s12031-018-1209-9#