ISI Papers With Our Products

Title: Morphological and physicochemical evaluation of the propranolol HCl–Eudragit® RS100 electrosprayed nanoformulations
Journal: Artificial Cells, Nanomedicine, and Biotechnology
Author: 1. Alireza Garjani, 1,2. Mohammad Barzegar-Jalali, Khosro Adibkia, 1,4. Hamed Ranjbara, 3. Karim Osouli-Bostanabad
Year: 2017
Address: 1. Faculty of Pharmacy, Tabriz University of Medical Sciences, Tabriz, Iran; 2. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; 3. Research Center for Pharmaceutical Nanotechnology, Tabriz University of Medical Sciences, Tabriz, Iran; 4. Students Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: The aim of this study was to fabricate propranolol hydrochloride (Prop. HCl) (as a water-soluble drug):EudragitVR RS100 (Eud) nanobeads and nanofibres applying the electrospraying method as an economical and one-step technique. Different ratios of Prop. HCl:Eud (i.e. 1:5 and 1:10) at total solution concentrations of 10–20% W/V were investigated. The FE-SEM studies revealed that morphology and size of the samples were highly affected by the solution concentration; so that, the nanobeads (a mean diameter of 82.9 nm) were formed in low concentration and at the highest concentration of the solution, nanofibres (a mean diameter of 232.3 nm) were resulted. Besides the morphological changes, the size of processed nanoformulations was increased with an increment of the solution concentrations. Xray diffraction results as well as DSC thermograms clearly indicated that the drug crystallinity decreased in the electrosprayed samples. Furthermore, in vitro dissolution test showed that the electrosprayed samples had relatively slower release patterns toward the pure drug and physical mixtures, where the samples with the drug:polymer ratio of 1:10 indicated a faster release rate toward 1:5 ratio; nevertheless, the concentration of the injected formulations did not remarkably impressed the release behaviours. The current study established the suitability of electrospraying method in the fabrication of the water-soluble drugs nanobeads/nanofibres; however, in vivo effectiveness of the prepared nanoformulations should be meticulously considered.
Keywords: Propranolol hydrochloride; EudragitVR RS100; nanobeads; nanofibres; electrospraying
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: http://www.tandfonline.com/doi/abs/10.1080/21691401.2017.1337027#="http://www.tandfonline.com" & "/doi/abs/10.1080/21691401.2017.1337027"#