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Title: Introducing humidity and temperature as important parameters determining the size of chitosan nanoparticles prepared by electrospray
Journal: Nanomedicine Research Journal
Author: 1. Mohsen Abedi Ostad, Roghaye Arezumand, Fatemeh Oroojalian, 1,3. Amir Amani, 2. Ali Hanafi,
Year: 2021
Address: 1. Department of Advanced Technologies, North Khorasan University of Medical Sciences, Bojnurd, Iran 2. Department of Organic Chemistry and Biochemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran 3. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran
Abstract: Particle size is an important parameter in determining the quality of drug delivery systems. In this study, the effect of four independent parameters on the size of nanoparticles, prepared via electrospray, was investigated using artificial neural networks (ANNs). The parameters included concentration of polymer, applied voltage, humidity and temperature, of which, the last two were investigated for the first time in this study. The developed ANNs model showed that applied voltage and temperature had small and reverse effects on the size. However, the dominant factors determining the size of the nanoparticles were humidity and polymer concentration: an optimum value was required for obtaining the smallest size.
Keywords: Chitosan, particle size, artificial neural networks, electrospray, polymer concentration, applied voltage, temperature, humidity
Application: Micro and Nanoparticles
Product Model 1: Electrospinning Setup
Product Model 2:
URL: #http://www.nanomedicine-rj.com/article_249487.html#