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Title: Design and performance investigation of electrospun PVA nanofibers containing core-shell nanostructures for anticancer drug delivery
Journal: Nanomedicine Research Journal
Author: 1. Sakineh Kavyanifar, Tayebeh Shamspur, 2. Fariba Fathirad
Year: 2018
Address: 1. Department of Chemistry, Faculty of Sciences, ShahidBahonar University of Kerman, Kerman, Iran 2. Department of Nanotechnology, Graduate University of Advanced Technology, Kerman, Iran
Abstract: Objectve: The purpose of this work was design and performance investgaton of a nanocarrier based on magnetc nanofbers containing core-shell nanostructuresfor antcancerdrug delivery of daunorubicin (DAN) by measuring their drug release at different pH values. Methods: Fe3O4 nanopartcles and Fe3O4@SiO2core-shell nanostructures were synthesized through coprecipitaton and Stöber methodrespectvely. The composite nanofbers of polyvinyl alcohol containing core-shell nanostructures and antcancer drug of daunorubicinwere fabricated by electrospinning method. The nanostructures were characterized bySEM, XRD,VSM and FTIR techniques. The drug release was investgated by UV-Vis spectrophotometer at different pHs. Results: The results is shown that in vitro drug release at pH= 6.0 is promisingly more and faster than drug release at pH= 7.4. The fted equaton of release curves is corresponded to Peppas model. Conclusions: It can be concluded that the proposed nanocarrier is capable of responding to pH changes, that is an advantage in the targeted delivery of the drug. Also, this method has the advantages of magnetc sensitvity, high drug loading capacity and sustained release.
Keywords: Core-Shell Nanostructure, Daunorubicin, Drug Release, Electrospun Nanofbers, Magneticnanocarrier
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: #http://www.nanomedicine-rj.com/article_31898.html#