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Title: Development and optimization of N-Acetylcysteine-loaded poly (lactic-co-glycolic acid) nanoparticles by electrospray
Journal: International journal of biological macromolecules
Author: 1. Ali Akbar Karimi Zarchi, 1,6. Amir Amani, 2. Shayan Abbasi, 3. Mohammad Ali Faramarzi, 4. Kambiz Gilani, 5. Mahmoud Ghazi-Khansari
Year: 2015
Address: 1. Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran 2. Institute of Biochemistry and Biophysics (I.B.B.), University of Tehran, Tehran, Iran 3. Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 4. Aerosol Research Laboratory, Department of Pharmaceutics, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran 5. Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran 6. Medical Biomaterials Research Center, Tehran University of Medical Sciences, Tehran, Iran
Abstract: N-Acetylcysteine (NAC) loaded PLGA nanoparticles were prepared by electrospray method. The influence of independent parameters such as concentration, flow rate and nozzle to collector distance was studied on particle size and size distribution of generated nanoparticles using a Box–Behnken experimental design. Smallest size was found to be obtained at minimum value for both flow rate and concentration of polymer, regardless of collecting distance value in the ranges studied. Additionally, the minimum value of size distribution was observed at lowest values of both concentration of polymer and collecting distance, regardless of flow rate value. In total, a sample with minimum size and polydispersity was predicted to have flow rate, polymer concentration and collecting distance values of 0.06 (ml/h), 0.5 (%w/w) and 9.28 (cm), respectively. The experimentally prepared nanoparticles with lowest size and size distribution values, had a size of 122 (nm) and size distribution of 24. Zeta potential, drug loading and encapsulation efficiency of optimized nanoparticles were −6.58, 5% and 54.5%, respectively.
Keywords: Electrospraying poly (lactic-co-glycolic acid) N-acetylcysteine Nanoparticles Optimization Particle size Size distribution
Application: Drug Delivery, Nanoparticle
Product Model 1: Syringe Pump (SP1000HOM)
Product Model 2: High Voltage Power Supply (HV 35P OC)
URL: http://www.sciencedirect.com/science/article/pii/S0141813014006011#="http://www.sciencedirect.com" & "/science/article/pii/S0141813014006011"#