ISI Papers With Our Products
Title: Towards optimization of odonto/osteogenic bioengineering: in vitro comparison of simvastatin, sodium fluoride, melanocyte-stimulating hormone
Journal: In Vitro Cellular & Developmental Biology-Animal
Author: 1. Vahid Zijah, 2. Roya Salehi, 2,6. Soodabeh Davaran, 3. Marziyeh Aghazadeh, 4. Mohammad Samiei, 5,6. Effat Alizadeh
Year: 2017
Address: 1. Dental Department, Behbood Hospital, Tabriz, Iran
2. Drug Applied Research Center and Department of Medical
Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz
University of Medical Sciences, Tabriz, Iran
3. Oral Medicine Department of Dental Faculty, Tabriz University of
Medical Sciences, Tabriz, Iran
4. Endodontics Department of Dental Faculty, Tabriz University of
Medical Sciences, Tabriz, Iran
5. Stem Cell Research Center and Department of Medical
Biotechnology, Faculty of Advanced Medical Sciences, Tabriz
University of Medical Sciences, Tabriz, Iran
6. Drug Applied Research Center, Tabriz University of Medical
Sciences, Tabriz, Iran
Abstract: Tissue engineering has emerged as a potential
therapeutic option for dental problems in recent years. One
of the policies in tissue engineering is to use both scaffolds
and additive factors for enhancing cell responses. This study
aims to evaluate and compare the effect of three types of
biofactors on poly-caprolactone-poly-ethylene glycol-poly
caprolactone (PCL-PEG-PCL) nanofibrous scaffold on human
dental pulp stem cell (hDPSCs) engineering. The PCLPEG-
PCL copolymer was synthesized with ring opening
polymerization method, and its nanofiber scaffold was prepared
by electrospinning method. Nanofibrous scaffoldseeded
hDPSCs were treated with sodium fluoride (NaF),
melanocyte-stimulating hormone (MSH), or simvastatin
(SIM). Non-treated nanofiber seeded cells were utilized as
control. The viability, biocompatibility, adhesion, proliferation
rate, morphology, osteo/odontogenic potential, and the
expression of tissue-specific genes were studied. The results
showed that significant higher results demonstrated significant
higher adhesive behavior, viability, alizarin red activity,
and dentin specific gene expression in MSH- and SIMtreated
cells (p < 0.05). This study is unique; in that, it
compares the effects of different treatments for optimization
of dental tissue engineering.
Keywords: Simvastatin . Sodiumfluoride .
Melanocyte-stimulating hormone . Human dental pulp stem
cells
Application: Scaffold, Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL: http://link.springer.com/article/10.1007/s11626-017-0141-6#="http://link.springer.com" & "/article/10.1007/s11626-017-0141-6"#