ISI Papers With Our Products



Title: Towards optimization of odonto/osteogenic bioengineering: in vitro comparison of simvastatin, sodium fluoride, melanocyte-stimulating hormone
Journal: In Vitro Cellular & Developmental Biology-Animal
Author: 1. Vahid Zijah, 2. Roya Salehi, 2,6. Soodabeh Davaran, 3. Marziyeh Aghazadeh, 4. Mohammad Samiei, 5,6. Effat Alizadeh
Year: 2017
Address: 1. Dental Department, Behbood Hospital, Tabriz, Iran 2. Drug Applied Research Center and Department of Medical Nanotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran 3. Oral Medicine Department of Dental Faculty, Tabriz University of Medical Sciences, Tabriz, Iran 4. Endodontics Department of Dental Faculty, Tabriz University of Medical Sciences, Tabriz, Iran 5. Stem Cell Research Center and Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran 6. Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran
Abstract: Tissue engineering has emerged as a potential therapeutic option for dental problems in recent years. One of the policies in tissue engineering is to use both scaffolds and additive factors for enhancing cell responses. This study aims to evaluate and compare the effect of three types of biofactors on poly-caprolactone-poly-ethylene glycol-poly caprolactone (PCL-PEG-PCL) nanofibrous scaffold on human dental pulp stem cell (hDPSCs) engineering. The PCLPEG- PCL copolymer was synthesized with ring opening polymerization method, and its nanofiber scaffold was prepared by electrospinning method. Nanofibrous scaffoldseeded hDPSCs were treated with sodium fluoride (NaF), melanocyte-stimulating hormone (MSH), or simvastatin (SIM). Non-treated nanofiber seeded cells were utilized as control. The viability, biocompatibility, adhesion, proliferation rate, morphology, osteo/odontogenic potential, and the expression of tissue-specific genes were studied. The results showed that significant higher results demonstrated significant higher adhesive behavior, viability, alizarin red activity, and dentin specific gene expression in MSH- and SIMtreated cells (p < 0.05). This study is unique; in that, it compares the effects of different treatments for optimization of dental tissue engineering.
Keywords: Simvastatin . Sodiumfluoride . Melanocyte-stimulating hormone . Human dental pulp stem cells
Application: Scaffold, Tissue Engineering
Product Model 1: Electroris
Product Model 2:
URL: http://link.springer.com/article/10.1007/s11626-017-0141-6#="http://link.springer.com" & "/article/10.1007/s11626-017-0141-6"#