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Title: Drug-loaded electrospun nanofibrous sheets as barriers against postsurgical adhesions in mice model
Journal: Nanomedicine Research Journal
Author: 1. Safieh Boroumand, Reza Faridi-Majidi, 2. Sara Hosseini, Mohammad Salehi
Year: 2017
Address: 1. Department of Medical Nanotechnology, School of Advanced Technology in Medicine, Tehran University
of Medical science, Tehran, Iran
2. Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University
of Medical Sciences, Tehran, Iran
Abstract: Objective(s): Postsurgical adhesion is one of the common complications after
surgery. Some anti-adhesion barriers are commercially available which are not
customarily used by physicians as much as expected because of ineffectiveness.
Recently, nanofibers have been introduced as anti-adhesion barriers with the
potential of drug delivery. In the light of role of inflammation and oxidative stress
in adhesion formation, it is supposed that curcumin as an anti-oxidant and antiinflammatory
agent is able to prevent postsurgical adhesions.
Methods: In the present study, curcumin-loaded nanofibrous sheets were
prepared using electrospinning and evaluated for its anti-adhesion profile in a
mice model. Scanning Electron Microscopy (SEM), Attenuated Total Reflectance
Fourier Transformed Infrared Spectroscopy (ATR-FTIR), drug release and
degradation investigations and also, in vivo studies were performed.
Results: curcumin-loaded nanofibers were successfully prepared and shown
significant prevention of postsurgical adhesion formation in mice model. Release
study indicated that after 30 days, about 30% of the drug is released from the
electrospun nanofibers. In vivo experiments showed that postsurgical adhesion
has been reduced about 50% compared to the control group.
Conclusions: Curcumin-loaded nanofibers have the potential to decrease
postsurgical adhesion formation as a barrier. This system supports the sustained
release of curcumin from the nanofibers.
Keywords: Postsurgical adhesion
Electrospinning
Curcumin
Application: Drug Delivery
Product Model 1: Electroris
Product Model 2:
URL: http://www.nanomedicine-rj.com/article_23780.html#="http://www.nanomedicine-rj.com" & "/article_23780.html"#